chronic GVHD regulatory T cells ameliorate ongoing + CD 4 + activated CD 103
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منابع مشابه
In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease.
CD103 (alphaEbeta7) has been shown to be an excellent marker for identifying in vivo-activated FoxP3(+)CD4(+) regulatory T (Treg) cells. It is unknown whether reinfusion of in vivo-activated donor-type CD103(+) Treg cells from recipient can ameliorate ongoing chronic graft-versus-host disease (GVHD). Here, we showed that, in a chronic GVHD model of DBA/2 (H-2(d)) donor to BALB/c (H-2(d)) recipi...
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CD4 CD25 T cells have been implicated in two apparently opposing functions, namely an activated effector function but also a regulatory function. In human hematopoietic stem cell transplantation (HSCT), the frequency of CD4CD25 T cells is increased and this increase was reported to correlate with graft-versus-host disease (GvHD), suggesting that the effector function predominates. In mice, CD4C...
متن کاملChanges of lymphocyte subsets in leukemia patients who received allogenic bone marrow transplantation.
Proportional changes of lymphocyte subsets in the peripheral blood were monitored by two-color flow-cytometry in seven leukemia patients who had received allogenic bone marrow transplantation (BMT). Lymphocyte counts, and proportions of T and B-cells returned to normal ranges between the 2nd and 12th months after BMT. Activated T-cells prominently increased after BMT, and the values gradually r...
متن کاملDistribution of CD 4 + CD 25 + T cells and graft - versus - host disease in human hematopoietic stem cell transplantation
CD25 + T cells in recipients after hematopoietic stem cell transplantation (HSCT) and their association with graft-versus-host disease (GVHD). Methods : Seventeen children who underwent HSCT were investigated. CD4 + CD25 + T cells in samples from donor grafts and recipient peripheral blood were assessed by flow cytometry at 1 and 3 months after transplantation. Results : CD4 + CD25 + T cell fre...
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